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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Cancer Res. 2019 Jul 3;79(16):4283–4292. doi: 10.1158/0008-5472.CAN-18-3139

Figure 6. Increasing hydrophobicity of the gatekeeper residue correlates with increased resistance to avapritinib, but has minimal effect on midostaurin.

Figure 6.

Average IC50s of (A) avapritinib and (B) midostaurin against various gatekeeper mutants. Each data point represents one experiment done in triplicate. The average IC50 of at least 3 separate experiments is shown in nM. The mutants are listed in order of increasing hydrophobicity of the gatekeeper residue, according to the Kyte-Doolittle hydrophobicity scale (58), as indicated by the blue gradient.