Table 2:

(A) Score assignment and sum scores for prognostic risk group and combined risk group. (B) Results from multivariable Cox regression models using the bootstrap method with 10000 times of resampling for prognostic scoring system. (C) Results from multivariable Cox regression models using the bootstrap method with 10000 times of resampling for cytogenetic risk classification. (D) Results from multivariable Cox regression models using the bootstrap method with 10000 times of resampling for combined risk classification.

(A) Score assignment and sum scores for prognostic risk group and combined risk group
	Score assignment
	0	1	1.5	2
Remission status	CR/PR	No CR/PR
Lymphocyte count & WBC	<2 & ≥2	-	≥2 & <10	(<2 & <2) or (≥2 & ≥10)
HCT-CI	0–1	≥2	-	-
Cytogenetics risk	no del(17p) & no Complex 5	del(17p) without Complex 3,4 or 5	-	del(17p) with Complex 3,4 or 5
		Complex 5 without del(17p)

Sum prognostic score	0	1	1.5–2.5	≥3
Prognostic risk group	Low	Intermediate	High	Very high
Prognostic and cytogenetic risk combined score	0	1–2	2.5–3.5	≥4
Combined risk group	Low	Intermediate	High	Very high

(B) Prognostic scoring system
		PFS			OS			NRM			Relapse
Risk Group	N	E	HR (95% CI)	p-value	E	HR (95% CI)	p-value	E	sHR (95% CI)	p-value	E	sHR (95% CI)	p-value
Low	184	75	ref		55	ref		34	Ref		41	ref
Intermediate	143	80	1.66 (1.18,2.33)	0.0024	59	1.68 (1.13, 2.5)	0.0082	43	1.89 (1.17, 3.13)	0.01	37	1.25 (0.78, 2.01)	0.35
High	143	97	2.36 (1.7, 3.3)	<0.0001	75	2.2 (1.53, 3.2)	<0.0001	41	1.78 (1.08, 2.97)	0.02	56	2.21 (1.44, 3.49)	<0.0001
Very high	132	97	2.7 (1.91, 3.83)	<0.0001	81	2.76 (1.87, 4.15)	<0.0001	57	2.68 (1.67, 4.49)	<0.0001	40	1.65 (1.01, 2.68)	0.047
E: number of events. Ref: reference group. HR: hazard ratio; sHR: subdistribution hazard ratio. NRM: non-relapse mortality.

(C) Cytogenetic risk classification
			PFS			OS			NRM			Relapse
Risk Group	N	E	HR (95% CI)	p-value	E	HR (95% CI)	p-value	E	sHR (95% CI)	p-value	E	sHR (95% CI)	p-value
Low	298	151	ref		114	ref		79	ref		72	ref
Int.	88	55	1.56 (1.1, 2.19)	0.012	43	1.5 (1.0, 2.22)	0.048	28	1.24 (0.73, 2.0)	0.41	27	1.52 (0.9, 2.49)	0.12
High	83	63	2.0 (1.4, 2.89)	<0.0001	51	1.89 (1.27, 2.75)	0.0016	26	1.24 (0.73, 2.06)	0.41	37	2.11 (1.28, 3.44)	0.006
E: number of events. Ref: reference group. Int.: intermediate risk. HR: hazard ratio; sHR: subdistribution hazard ratio. NRM: cumulative incidence of non-relapse mortality; Relapse: cumulative incidence of relapse.

(D) Combined Risk Classification
		PFS			OS
Risk Group	N	E	HR (95% CI)	p-value	E	HR (95% CI)	p-value
Low	116	43	ref		30	ref
Intermediate	173	96	1.92 (1.32, 2.89)	0.0006	72	1.98 (1.26, 3.32)	0.004
High	94	63	2.62 (1.67, 4.1)	<0.0001	50	2.63 (1.59, 4.57)	<0.0001
Very high	86	67	3.71 (2.44, 5.87)	<0.0001	56	4.0 (2.43, 6.90)	<0.0001
E: number of events. Ref: reference group. Int.: intermediate risk. HR: hazard ratio; sHR: subdistribution hazard ratio. NRM: cumulative incidence of non-relapse mortality; Relapse: cumulative incidence of relapse.