Table 1:

Distribution of pre-treatment patient characteristics for the TMZ+RT arm of three clinical studies and three RWE studies.

Study	DFCI-cohort	UCLA-cohort				AVAglio
NCT ID					---
PubMed ID			PM21135282	PM25910950	PM22120301	PM24552318
Datatype	RWE	RWE	RWE	Phase II	Phase II	Phase III
Arm	TMZ+RT	TMZ+RT	TMZ+RT	TMZ+RT	TMZ+RT	TMZ+RT
Enrollment period			8/06–11/08	2/09–6/11	8/05–2/11	6/09–3/11
Enrollments to SOC	378	305	110	29	16	460
OS Events	269	265	89	24	15	344
Age
Median	58	57	59	58	59	57
Range	18–91	20–84	20–90	26–73	36–69	18–79
SD	13	13	14	11	11	10
Sex (%)
Females	0.43	0.36	0.36	0.45	0.5	0.36
Males	0.57	0.64	0.64	0.55	0.5	0.64
KPS (%)
<=80	0.55	0.39	0.32	0.24	0.44	0.31
>80	0.45	0.61	0.68	0.76	0.56	0.69
Data missing (n)	27	17	0	0	0	0
RPA (%)
3	NA	0.22	0.25	NA	0.12	0.16
4	NA	0.42	0.41	NA	0.75	0.61
5	NA	0.34	0.33	NA	0.13	0.23
6	NA	0.02	0.01	NA	0	0
Data missing (n)	378	0	0	29	1	0
Resection (%)
Biopsy	0.14	0.22	0.21	0.21	0	0.09
Sub Total	0.47	0.47	0.36	0.48	0.31	0.49
Gross Total	0.39	0.31	0.43	0.31	0.69	0.42
Data missing (n)	12	15	0	0	0	0
MGMT (%)
Unmethylated	0.43	0.71	0.60	0.86	0.43	0.67
Methylated	0.57	0.29	0.40	0.14	0.56	0.32
Data missing (n)	194	128	40	7	0	0.23
IDH1 (%)
Wildtype	0.91	0.91	0.98	0.83	NA	NA
Mutant	0.09	0.09	0.02	0.17	NA	NA
Data missing (n)	188	0.46	52	6	16	344

Abbreviations: KPS, Karnofsky performance status; MGMT, O6-methylguanine-DNA methyltransferase; RPA, recursive partitioning analysis; IDH1, isocitrate dehydrogenase 1.