Table 2:

Pre-treatment patient characteristics associated with OS. Estimated hazard-ratios in univariable and multivariable stratified Cox regression models. The baseline hazard rate was stratified by study and treatment arm.

Model	Univariable		Multivariable
Variables	HR	p-value	HR	p-value
Age
Linear	1.02	<0.001	1.03	<0.001
Sex (Ref. Female)	1		1
Male	1.17	0.004	1.15	0.012
KPS (Ref. <= 80)	1		1
>80	0.64	<0.001	0.78	<0.001
RPA (Ref. Class 3)	1		1
Class 4	1.50	<0.001	0.90	0.327
Class 5	2.29	<0.001	1.04	0.734
Class 6	7.10	<0.001	2.20	0.059
Resection (Ref. Biopsy)	1		1
Sub Total	0.78	0.001	0.82	0.028
Gross Total	0.56	<0.001	0.62	<0.001
MGMT (Ref. Unmethylated)	1		1
Methylated	0.47	<0.001	0.46	<0.001
IDH1 (Ref. Wilde-Type)	1		1
Mutant	0.35	<0.001	0.52	0.010