KEY RESOURCE TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
RNase L Rabbit monoclonal antibody	Cell Signaling Technology	CAT# D4B4J
Anti-rabbit IgG HRP-linked antibody	Cell Signaling Technology	CAT# 7074S
β-actin Mouse monoclonal antibody	Cell Signaling Technology	CAT# 3700S
RNase L Mouse monoclonal antibody	Santa Cruz Biotechnology	CAT# sc-74405
Chemicals, Peptides, and Recombinant Proteins
2’-5’ A4 oligoadenylate	Chemgenes	N/A
2’-5’ A2/A3/A4 linked to amine (2’-5’ An-NH2)	Chemgenes	N/A
TGP-210	(Costales et al., 2017)	N/A
TGP-210–2’-5’ A2/A3/A4 (TGP-210-RL)	This paper	N/A
SYTO 82 Orange Fluorescent Nucleic Acid Stain	Invitrogen	CAT# S11363
Critical Commercial Assays
Quick-RNA Miniprep Kit	Zymo	CAT# R1055
miRNeasy Mini Kit	Qiagen	CAT# 217004
Caspase-Glo 3/7 Assay	Promega	CAT# G8091
Oligonucleotides
Control siRNA-A	Santa Cruz Biotechnology	CAT# sc-37007
RNase L siRNA (h)	Santa Cruz Biotechnology	CAT # sc-45965
Primers used for RT-qPCR, see Table S2	Integrated DNA Technologies/Eurofins MWG Operon	N/A
hsa-miR-210-3p, miRCURY LNA Power microRNA inhibitor	Qiagen	CAT# YI04103145-DDA
Negative control A, miRCURY LNA Power microRNA inhibitor control	Qiagen	CAT# YI00199006-DFA
5’ FAM/3’ BHQ miR-210 Hairpin Precursor	Chemgenes	N/A
5’ Cy5 miR-210 Hairpin RNA	Integrated DNA Technologies	N/A
5’ Cy5 miR-210 Mutant RNA	Integrated DNA Technologies	N/A
5’ Cy5 DNA Hairpin	Integrated DNA Technologies	N/A
Recombinant DNA
pEZX-MR04 – miR-210 overexpression plasmid	Genecopoeia	CAT# HmiR0167-MR04
pcDNA3-RNaseL – RNase L overexpression plasmid	(Dong et al., 2001)	N/A
pGEX-4T-RNaseL-GST – RNase L protein expression plasmid	(Dong and Silverman, 1997)	N/A
Deposited Data
RNA-Seq data	This paper	GEO Accession:
Software and Algorithms
NT Analysis 1.5.41	Nanotemper Technologies	N/A
TargetScanHuman v7.2	(Agarwal et al., 2015)	N/A
QuantityOne	BioRad	N/A
ImageJ	NIH	N/A
Olympus Fluoview software version 3.0	Olympus	N/A
GraphPad Prism 7	GraphPad Prism Software, Inc.	N/A