Table 3. Clinical and immunophenotypic characteristics of the samples used for methylome analysis.
| Clinical and immunophenotypic characteristics | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CLL patients | Sample ID | Age | Sex | Smoking status | BMI | CD5+ (%) | CD5+/CD19+ (%) | CD23+ (%) | CD38+ (%) | IGHV mutational status | Lymphocyte count/mm3 | SHANK1 Methylation value (%) |
| 304012 002 | 67 | M | No Smoker | 19,6 | NA | NA | NA | NA | NA | NA | 59 | |
| 304012 007 | 81 | M | No Smoker | 23,8 | 93.30 | 71.50 | 72.10 | 42 | Positive | 5050 | 23 | |
| 304012 030 | 67 | M | No Smoker | 27,2 | 98.60 | 92 | 92 | 2.6 | Negative | 32380 | 51 | |
| 304012 048 | 64 | F | No Smoker | 26,7 | 94.1 | 78.70 | 75.40 | 15 | Negative | 9580 | 57 | |
| 304032 083 | 75 | M | Smoker | 32,9 | NA | NA | NA | NA | NA | NA | 75 | |
| 304012 088 | 79 | M | No Smoker | 33,8 | 98.2 | 91 | 91.4 | 4.7 | Negative | 45330 | 63 | |
| 304012 092 | 64 | M | No Smoker | 26,9 | 88.7 | 64.8 | 63.7 | 10 | Positive | 21830 | 32 | |
| 304012 112 | 83 | F | No Smoker | NA | 34 | 6 | 70.3 | 14 | Negative | 5270 | 27 | |
| 304012 114 | 73 | M | No Smoker | 25,5 | Negative/ weak | NA | 65 | 16 | Negative | 24360 | 36 | |
| 304012 188 | 43 | F | No Smoker | 21,0 | 97 | 87 | 88 | 9 | Positive | 5410 | 16 | |
| 304012 193 | 52 | M | Smoker | 30,8 | 56 | NA | NA | NA | Negative | 58880 | 69 | |
| 304012 196 | 58 | F | No Smoker | 18,6 | 68 | 54 | 76 | NA | Negative | 9060 | 44 | |
| 304012 198 | 48 | F | No Smoker | 21,9 | NA | NA | NA | NA | NA | NA | 10 | |
| 304012 475* | 60 | M | No Smoker | 23,0 | 97.9 | 94.60 | Partially expressed | Weak | Positive | 94100 | 69 | |
| Controls | 304012 357 | 37 | F | No Smoker | 24,7 | – | – | – | – | – | – | 9 |
| 304012 368 | 68 | M | No Smoker | 30,8 | – | – | – | – | – | – | 10 | |
| 304012 427 | 47 | M | No Smoker | 26,8 | – | – | – | – | – | – | 10 | |
| 304012 429 | 69 | M | No Smoker | 28,1 | – | – | – | – | – | – | 13 | |
| 304012 448 | 67 | F | No Smoker | 21,7 | – | – | – | – | – | – | 16 | |
| 304012 455 | 20 | M | Smoker | 21,7 | – | – | – | – | – | – | 8 | |
For 4/18 patients with CLL diagnosis used for methylome analysis, clinical and immunophenotypic characteristics were not available. * this patient was firstly diagnosed as Follicular lymphoma.