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. 2019 Aug 12;12:6361–6370. doi: 10.2147/OTT.S210800

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© 2019 Wei et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Overexpression of MTHFD2 in CRC cell RKO and SW-480 promoted cell proliferation and migration. (A) MTHFD2 mRNA and protein expression levels were measured in RKO and SW-480 cells after transfection with the MTHFD2 vector. (B) Colony-forming experiment showed the cell proliferative capacity of RKO and SW-480 cells after overexpression of MTHFD2. (C) MTT assay analysis showed the cell growth of RKO and SW-480 cells after overexpression of MTHFD2. (D) Transwell cell migration assay showed the cell migration ability of RKO and SW-480 cells after overexpression of MTHFD2. (*P<0.05, **P<0.01, ***P<0.001, compared with the control group).

Abbreviations: MTHFD2, Methylenetetrahydrofolate dehydrogenase 2; CRC, colorectal cancer.