Table 3.
Chi-square analyses for the frequency of relevant dysregulation in the downstream target RNAs.
| Targeted by dysregulated upstream miRNAs | Dysregulation of downstream mRNAs | Odds Ratio† | 95% Confidence interval | P value |
|---|---|---|---|---|
| A | ||||
| 7 M up-regulated miRNAs | Down-regulation | 1.123 | 0.950–1.327 | 0.175 |
| 7 M down-regulated miRNAs | Up-regulation | 0.495 | 0.304–0.806 | 0.004* |
| 12 M up-regulated miRNAs | Down-regulation | 0.722 | 0.563–0.926 | 0.010* |
| 12 M down-regulated miRNAs | Up-regulation | 0.763 | 0.543–1.073 | 0.119 |
| Targeted by dysregulated upstream circRNAs | Dysregulation of downstream miRNAs | Odds Ratio | 95% Confidence interval | P value |
| B | ||||
| 7 M up-regulated circRNAs | Down-regulation | 0.484 | 0.063–3.739 | 0.478 |
| 7 M down-regulated circRNAs | Up-regulation | 1.065 | 0.436–2.604 | 0.889 |
| 12 M up-regulated circRNAs | Down-regulation | — | — | 1.000 |
| 12 M down-regulated circRNAs | Up-regulation | 4.037 | 0.362–45.025 | 0.260 |
†Odds ratios for the frequency of significant dysregulation in the downstream RNAs, according to whether being targeted by the upstream RNAs, *P < 0.05, and **P < 0.01.