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. 2019 Aug 16;9:11954. doi: 10.1038/s41598-019-48434-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antigen specificity of the top 200 clonotypes of HEU (n = 19) and HU (n = 9) cord blood samples. Antigen specificity was determined using the VDJdb database and the following search parameters: (1) full matching of CDR3, T cell receptor beta variable and joining genes (TRBV, TRBJ) sequences, (2) VDJdb confidence score of at least 1, and (3) the following number of allowable substitutions (s = 2), indels (id = 1), and total number of mutations (t = 2). Median frequency of clones per group per antigen species are given as box plots. Dot plots are superimposed with the respective individual clonal frequencies. Each dot represents an individual clone. Expanded clonotypes were defined as clonotypes with a minimum frequency of 0.01 within samples showing a Shannon diversity score of 5.0 or less.