Fig. 3.

Substrate-binding cavity of the BorA DH M3 and FluA DH M1. a Close-up of the BorA DH M3 substrate-binding cavity, key residues and depiction of the three regions. The three binding regions include the PPant-binding, catalytic and acyl intermediate-binding region. Due to poor electron density, 11 amino acids between α3 and β11 are unmodeled, therefore, given an incomplete model of the substrate-binding cavity. b Close-up of the FluA DH M1 substrate-binding cavity. The variable loop regions are highlighted in red and blue residues of the cartoon model (colour figure online)