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. 2019 Jun 7;46(8):1167–1178. doi: 10.1007/s10295-019-02202-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — K0 main peak ratio as a function of the acidic (a) and basic variant (b) ratio. c Acidic area and d basic area as a function of the K0 main peak area. The ratio of the K0 peak area to the e acidic area and the f basic area as a function of glucose concentration. g Acidic peak area concentration at time point t as a function of D(t), that is, the product of newly built IgG concentration and glucose concentration integrated over time. 37 °C + Feed 1 [filled square], 37 °C + Feed 2 [filled diamond], 37 °C + Feed 3 [filled hexagon], 34 °C + Feed 1 [unfilled square], 34 °C + Feed 2 [unfilled diamond], 34 °C + Feed 3 [unfilled hexagon], 31 °C + Feed 1 [grey square], 31 °C + Feed 2 [grey diamond], 31 °C + Feed 3 [grey hexagon]