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. 2019 Jun 7;46(8):1167–1178. doi: 10.1007/s10295-019-02202-5

Table 2.

Charge heterogeneity distribution consistency of the control standards and supernatant samples determined by the described CEX method using the pH 7 buffer system

Sample Variant Relative area ± σ (%)
Pharmaceutical standard (n = 15) Acidic 16.2 ± 1.3
Main 59.2 ± 1.6
Basic 24.5 ± 0.8
Fed-batch samples drawn at day 4 (n = 8) Acidic 69.2 ± 3.0
Main 24.6 ± 2.5
Basic 6.6 ± 1.7