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. 2019 Jul 29;203(5):1298–1312. doi: 10.4049/jimmunol.1900104

FIGURE 2.

FIGURE 2.

IRSh impact on survival and immune response to sepsis. (A) Survival curve. The survival of animals in the four experimental groups after cecum ligation/perforation was plotted in a Kaplan–Meier curve. The log-rank (Mantel–Cox test) revealed a p value < 0.0001 (n = 113). Dotted lines indicate the 95% confidence interval for each curve. (B) Mean expected lifetime. Statistical significance was calculated by two-way ANOVA followed by Tukey multiple comparisons test for IRSh and saline groups. The means with 95% confidence interval are indicated. ****p < 0.0001. (C) Spleen weight and immune response in murine sepsis. Two-way ANOVA followed by Holm–Sidak test were used to show correlation between spleen weight and survival (p < 0.0001). Saline (control): 30 dead animals; imipenem: 28 dead and 3 survivors; IRSh: 27 dead; and IRSh plus imipenem: 13 dead and 15 survivors. The means with 95% confidence interval are indicated. ****p < 0.0001.