Fig. 4.

Accumulation of Aβ in the retina of LXRβ^−/− mice. There were only occasional Aβ deposits in the retina of 6-mo-old WT or LXRβ^−/− mice (A–D). However, in 16-mo-old mice there was a large amount of Aβ deposition in and around the ganglion cells in the retina of LXRβ^−/− mice but very little in the WT mice at this age. (***P < 0.001) (E–I). n = 4. (Scale bars: A, C, E, and G, 50 μm; B, D, F, and H, 20 μm.)