Fig. 7.

Loss of oligodendrocytes in the optic nerve of LXRβ^−/− mice. There were Oligo2-positive (red) cells and GS-positive (green) oligodendrocyte cells in the optic nerve of 6-mo-old WT mice (A–C). Although there was no difference in the number of Oligo2-positive cells in the optic nerve of 6-mo-old LXRβ^−/− mice, there were fewer GS-positive oligodendrocytes (D–F). In 16-mo-old mice, there were fewer Oligo2-positive and GS-positive oligodendrocytes (***P < 0.001) in the optic nerve of 16-mo-old LXRβ^−/− mice (G–M). n = 4. (Scale bars: A–L, 50 μm.)