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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: J Med Chem. 2017 Dec 13;60(24):10092–10104. doi: 10.1021/acs.jmedchem.7b01250

Figure 3.

Figure 3.

Activity of 5 and 13 on α4β2 nAChR and α3β4 nAChR in HEK cells. (A) Both 5 and 13 alone have no agonistic activity on α4β2 nAChR. (B) 5 and 13 potently inhibit epibatidine-induced α4β2 nAChR activation in a dose-dependent manner. (C) Both 5 and 13 alone only stimulate α3β4 nAChR at high dose. (D) 5 and 13 partially block epibatidine-induced α3β4 nAChR activation only at high dose. All experiments are performed in triplicate and repeated at least twice. Data are presented as mean ± SEM.