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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: J Med Chem. 2017 Dec 13;60(24):10092–10104. doi: 10.1021/acs.jmedchem.7b01250

Figure 5.

Figure 5.

Effect of 5 on relapse-like behavior. 5 blocked nicotine priming-induced as well as cue-induced reinstatement of nicotine seeking. (A) There was significant reinstatement induction by subcutaneous administration of a nicotine priming dose of 0.15 mg/kg. Pretreatment with 5 (0.3 and 1 mg/kg) returned lever pressing to the extinction (EXT) levels. (B) Reinstatement of lever pressing was also obtained upon presentation of stimuli (cue light, orange odor) previously associated with nicotine. Pretreatment with 5 (1 mg/kg) abolished reinstatement. Values represent the mean (±SEM) number of total responses on the nicotine-associated lever in 60 min for both reinstatement paradigms: (#) p < 0.05, (##) p < 0.01 difference from EXT; (∗) p < 0.05 difference from vehicle (5, 0 mg/kg). For detailed statistics, see “Results”.