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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: J Med Chem. 2017 Dec 13;60(24):10092–10104. doi: 10.1021/acs.jmedchem.7b01250

Figure 6.

Figure 6.

Assessment of body temperature. 5 failed to block nicotine- induced hypothermia and did not induce per se hypothermia. Baseline rectal temperature was measured just prior to injection of 5 (1.0 mg/ kg, sc) or vehicle (0.9% saline). Ten minutes later, nicotine (0.5 mg/ kg, sc) or vehicle (0.9% saline) was injected, and temperature was measured again after 15, 30, 60, and 120 min. Values represent the mean (±SEM) body temperature (°C): (###) p < 0.001 difference from T =0 for the nicotine group; (***) p < 0.001 difference from 5/ VEH and VEH/VEH at T =15 and T = 30. For detailed statistics, see “Results”.