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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: J Med Chem. 2017 Dec 13;60(24):10092–10104. doi: 10.1021/acs.jmedchem.7b01250

Scheme 1. General Synthetic Scheme Used for the Synthesis of Core A Type Compoundsa.

Scheme 1.

aStandard Boc coupling protocol utilizing repetitive (a1) 5% DIEA/95% DCM; (a2) Boc-AA, DIC, HOBt, DMF; 1. (b1) 55% TFA/45% DCM; (b2) 5% DIEA/95% DCM; COOH, DIC, HOBt, DMF; 2. (c) 40× BH3/THF (65 °C, 72 h); piperidine (65 °C, 18 h); 3. (d) 5× BrCN/0.1 M DCM (shaking12 h); 4. (e) HF/anisole, (0 °C, 7 hr); 5.