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. Author manuscript; available in PMC: 2019 Aug 17.
Published in final edited form as: J Med Chem. 2017 Dec 13;60(24):10092–10104. doi: 10.1021/acs.jmedchem.7b01250

Table 3.

Ki (nM) Values for 5 and 13 at Various nAChR Subtypesa

compd α4β2 α3β4 α4β4 α3β2 α3β4α5
5 18.0 ± 2.68  1026 ± 254  716 ± 200 167 ± 20.4 1619 ± 93.7
13 13.06 ± 0.55  964 ± 193  184 ± 28.7 85.4 ± 9.64 957 ± 70.6
a

All experiments are performed in triplicate and repeated 3−4 times. Data are presented as the mean ± SEM.