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Inhibitory functions of isolated mAbs on proteolysis of physiological/macromolecular substrates. (A) Fab L13 blocked MMP-9 from hydrolyzing type I collagen. (B) Inhibition of Aβ40 formation by IgG B2B2 in cellular assays. HEK293F cell cultures expressing APP571–696 were incubated with IgG for 72 h. Generated Aβ40 was measured by ELISA. (C) Fab A4A1 blocked Alp2 from hydrolyzing FITC-conjugated type I collagen.
