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Inhibition mechanisms of anti-MMP9 Fabs. (A) Lineweaver–Burk plots of cdMMP-9 in the presence of 62.5, 250, and 500 nM Fab L13 (Left) or 66, 33, and 16.5 nM Fab H4 (Right). (B) Competitive ELISA of Fab L13 (Left) or Fab H4 (Right) on immobilized cdMMP-9 in the presence of 1 to 125 nM nTIMP-2.
