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. 2019 Jul 29;116(33):16583–16592. doi: 10.1073/pnas.1819133116

Fig. 2.

Fig. 2.

Functional absence of vCA1-PVIs by TeNT impaired social memory. (A) AAV-CMV-DIO-TeNT-GFP was injected into the vCA1 of PV-Cre mice. TeNT could selectively block transmitter release in PVIs. (B) Representative coronal sections of a vCA1-PV-TeNT mouse, which were stained with anti-GFP (green), PV (red), and DAPI (blue). (C and E) Total duration in sniffing area during the SDT observed in PV-GFP (n = 12) and PV-TeNT mice (n = 11) (C) and SOM-GFP (n = 6) and SOM-TeNT (n = 7) mice (E). (D and F) Comparisons of SDI in experiment of PV-TeNT (D) and SOM-TeNT (F). (G) Protocol for 3-chamber sociability test. (H and I) During social interaction session, both groups spent more time in the social than nonsocial chamber (GFP: n = 15; TeNT: n = 16) (H); comparison of social interaction index (I). (J and K) During social novelty session, PV-TeNT mice did not display a preference for novel mouse (J); comparison of social novelty index (K). FM, familiar mouse; NM, novel mouse. All data are expressed as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.