Table 1: MESSI population with genotype and plasma ANG2 measured.
Continuous data are compared by the Wilcoxon ranksum test and categorical data by a chi square test. SOFA: sequential organ failure assessment score; ABG: arterial blood gas; PBW: predicted body weight. PEEP: positive end-expiratory pressure.
| ARDS (n=289) | Non-ARDS (n=414) | p-value | |
|---|---|---|---|
| Age | 60 (51 – 69) | 62 (52 – 71) | 0.095 |
| Female | 119 (41.2%) | 181 (43.7%) | 0.502 |
| European ancestry | 178 (61.6%) | 226 (54.6%) | 0.022 |
| African ancestry | 91 (31.5%) | 163 (39.4%) | |
| Asian ancestry | 13 (4.8%) | 16 (3.9%) | |
| Genetically admixed | 7 (2.4%) | 9 (2.2%) | |
| APACHE III | 84 (69 – 105) | 71 (57 – 88) | <0.001 |
| Infectious source (primary) | <0.001 | ||
| Pulmonary | 172 (60%) | 137 (33%) | |
| Genitourinary | 16 (6%) | 71 (17%) | |
| Abdominal | 38 (13%) | 63 (15%) | |
| Blood | 12 (4%) | 44 (11%) | |
| Unknown | 35 (12%) | 67 (16%) | |
| Comorbidities | |||
| Immunocompromised | 142 (49%) | 190 (46%) | 0.397 |
| Malignancy | 108 (37%) | 141 (34%) | 0.366 |
| Cirrhosis, decompensated | 23 (8%) | 13 (3%) | 0.004 |
| Diabetes | 76 (26%) | 139 (34%) | 0.043 |
| SOFA score day 0 | 5 (3 – 7) | 3 (1 – 5) | <0.001 |
| PaO2/FiO2 ratio day 0 | 122 (76 – 190) | 215 (117 – 323) | <0.001 |
| Number, % with ABG on day 0 | n=222, 77% | n=119, 29% | |
| Intubated on day 0 | 192 (66%) | 69 (17%) | <0.001 |
| Tidal volume per kg PBW | 7.1 (6.4 – 8.1) | 7.3 (6.8 – 8.6) | 0.213 |
| PEEP (cm H2O) | 5(5–8) | 5(5–5) | 0.012 |
| Plateau pressure (cm H2O) | 23 (18 – 30) | 20(17 – 24) | 0.049 |
| Vasoactive support day 0 | 181 (63%) | 159 (39%) | <0.001 |
| Measured ANG2 ng/ml | 10.0 (5.2 – 21.6) | 7.9 (3.9 – 16.0) | <0.001 |
| Mortality, 30 day | 197 (68.2%) | 157 (38.0%) | <0.001 |