Table 2: Five unlinked SNPs are cis quantitative trait loci (QTL) for plasma ANG2 expression during sepsis in Europeans, and 2 demonstrate significant ARDS association.

ARDS analyses were adjusted for the first 2 components of genetic ancestry, APACHE III score, and pulmonary (vs non-pulmonary) source of infection. MAF: minor allele frequency. QTL: quantitative trait loci. CI: confidence interval.

SNP	QTL Coefficient (95% CI)	p-value	ARDS MAF	Non ARDS MAF	Adjusted OR ARDS (95% CI)	p-value
rs2442608G	0.22 (0.09, 0.36)	0.001	0.51	0.44	1.38 (1.01, 1.87)	0.042
rs2922870G	−0.21 (−0.34, −0.08)	0.002	0.42	0.41	1.02 (0.76, 1.36)	0.905
rs2442630G	0.76 (0.27, 1.25)	0.002	0.04	0.01	5.48 (1.68, 17.8)	0.005
rs2515466A	−0.22 (−0.36, −0.07)	0.003	0.27	0.31	0.80 (0.58, 1.11)	0.189
rs6981002C	−0.44 (−0.73, −0.14)	0.004	0.04	0.03	1.28 (0.60, 2.72)	0.525