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. 2019 Aug 16;20:186. doi: 10.1186/s12931-019-1163-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Time trends in baseline mean SGRQ score (left panel) and baseline mean FEV₁ (right panel). Baseline values are available for 27 and 50 of the 55 studies, respectively. Correlation coefficients are − 0.50 for SGRQ, and + 0.36 for FEV₁. The red dashed lines illustrating the trends are least-squares fits to the data