Table 4.
Parameter estimates (analogous to Table 2) for regression analyses adjusting for SGRQ score or FEV1
| Parameter | Estimate | Implied percentage change | pB |
|---|---|---|---|
| Adjusting for SGRQ (28 studies): | |||
| Rate intercept β0 | 0.760 (−1.301, 2.804) | ||
| Rate slope β1 (publication year) | −0.096 (− 0.130, − 0.058) | −9.114 (− 12.205, − 5.644) | < 0.001 |
| Rate slope β2 (SGRQ score) | −0.001 (− 0.041, 0.038) | −0.093 (− 4.015, 3.923) | 0.961 |
| Rate random effect σλ | 0.247 (0.145, 0.415) | ||
| Overdispersion mean μφ | 0.263 (−0.645, 0.917) | ||
| Overdispersion random effect σφ | 0.954 (0.414, 1.723) | ||
| adjusting for FEV1 (50 studies): | |||
| Rate intercept β0 | 1.674 (0.876, 2.482) | ||
| Rate slope β1 (publication year) | −0.050 (−0.079, − 0.022) | −4.912 (− 7.598, − 2.172) | 0.001 |
| Rate slope β2 (FEV1) | − 0.028 (− 0.046, − 0.011) | −2.810 (− 4.517, −1.093) | 0.002 |
| Rate random effect σλ | 0.374 (0.279, 0.498) | ||
| Overdispersion mean μφ | − 0.150 (−1.008, 0.340) | ||
| Overdispersion random effect σφ | 0.726 (0.299, 1.508) | ||
| Adjusting for SGRQ and FEV1 (25 studies): | |||
| Rate intercept β0 | 2.664 (−0.261, 5.583) | ||
| Rate slope β1 (publication year) | −0.045 (− 0.102, 0.008) | −4.404 (−9.737, 0.816) | 0.094 |
| Rate slope β2 (SGRQ score) | −0.009 (− 0.051, 0.035) | −0.849 (− 4.963, 3.610) | 0.690 |
| Rate slope β3 (FEV1) | −0.042 (− 0.079, − 0.004) | −4.131 (− 7.614, − 0.369) | 0.032 |
| Rate random effect σλ | 0.269 (0.161, 0.426) | ||
| Overdispersion mean μφ | 0.123 (− 0.777, 0.777) | ||
| Overdispersion random effect σφ | 0.744 (0.273, 1.598) | ||