Table 1.
Clinicopathological characteristics
| Stage II: n = 53 (%) |
Stage III: n = 54 (%) |
|||||
|---|---|---|---|---|---|---|
| MVD-low n = 26 (%) | MVD-high n = 27 (%) | P-value | MVD-low n = 15 (%) | MVD-high n = 39 (%) | P-value | |
| Sex | ||||||
| Male | 14 (53.8) | 14 (51.8) | 10 (66.7) | 25 (64.1) | ||
| Female | 12 (46.2) | 13 (48.2) | 0.88 | 5 (33.3) | 14 (35.9) | 0.86 |
| Age, mean (s.d.) in years | 73.7 (11.3) | 70.9 (13.3) | 0.41 | 63.6 (9.8) | 66.6 (10.1) | 0.32 |
| Right sided tumour | 9 (34.6) | 8 (29.6) | 0.70 | 7 (46.7) | 18 (46.2) | 0.97 |
| Tumour diameter, mean (s.d.) in mm | 39.2 (20.7) | 40.80 (19.3) | 0.61 | 36.4 (10.5) | 33.9 (13.4) | 0.44 |
| Histological grade | ||||||
| Good | 2 (7.7) | 3 (11.1) | 1 (6.7) | 1 (2.6) | ||
| Average | 23 (88.5) | 23 (85.2) | 12 (80.0) | 35 (89.7) | ||
| Poor | 1 (3.8) | 1 (3.7) | 0.91 | 2 (13.3) | 3 (7.7) | 0.61 |
| Tumour stage | ||||||
| T1 | – | – | 1 (2.6) | |||
| T2 | – | 1 (6.7) | 6 (15.4) | |||
| T3 | 23 (88.5) | 26 (96.3) | 10 (66.7) | 30 (76.9) | ||
| T4 | 3 (11.5) | 1 (3.7) | 0.28 | 4 (26.7) | 2 (5.1) | 0.13 |
| Nodal stage (stage III) | ||||||
| N1 | – | – | 12 (80.0) | 22 (56.4) | ||
| N2 | – | – | – | 3 (20.0) | 17 (43.6) | 0.11 |
| Mucinous differentiation. | 8 (30.8) | 4 (14.8) | 0.17 | 1 (6.7) | 4 (10.3) | 0.68 |
| Ulceration | 18 (69.2) | 23 (85.2) | 0.17 | 10 (66.7) | 35 (89.7) | 0.042* |
| Angioinvasion | 2 (7.7) | 4 (14.8) | 0.41 | 7 (46.7) | 14 (35.9) | 0.47 |
| Perforation | ||||||
| No | 24 (92.3) | 24 (88.9) | 14 (93.3) | 37 (94.9) | ||
| Before surgery | 1 (3.8) | 1 (3.7) | 1 (6.7) | 1 (2.6) | ||
| During surgery | – | 1 (3.7) | – | – | ||
| After surgery | 1 (3.8) | 1 (3.7) | 0.81 | – | 1 (2.6) | 0.64 |
| Tumour spill | 1 (3.8) | 2 (7.4) | 0.58 | 1 (6.7) | – | 0.10 |
| Adjuvant chemo | 0 | 0 | – | 15 (100.0) | 39 (100.0) | – |
| Recurrence | 6 (23.1) | 12 (44.4) | 0.10 | 11 (73.3) | 14 (35.9) | 0.013* |
| CRC mortality | 6 (23.1) | 9 (33.3) | 0.41 | 8 (53.3) | 12 (30.8) | 0.12 |
| Overall mortality | 14 (53.8) | 16 (59.3) | 0.69 | 9 (60.0) | 17 (43.6) | 0.28 |
| Follow up, mean (s.d.) in months | 70.5 (32.6) | 58.1 (35.9) | 0.19 | 52.3 (33.7) | 57.7 (27.4) | 0.54 |
Baseline characteristics and clinicopathological data stratified for low and high MVD for both stage II and III colon cancer. P-values were calculated by chi-square test or independent t-testing for continuous data
*Significant p-value < 0.05