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. 2019 Aug 16;24:53. doi: 10.1186/s11658-019-0178-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The three forms of covalently joined circRNAs in cells: exon-exon, exon-intron (intronic), and intron-intron (intronic-intronic). circRNAs may serve as miRNA sponges to prevent binding to target genes