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. 2019 Aug 16;38:360. doi: 10.1186/s13046-019-1368-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CBP induces intrinsic apoptosis. a) Protein expression levels of p53 and apoptotic markers in MM cell lines after 20 μM CPB for 24, 48 and 72 h treatments analysed by Western blot analysis. Histograms report the expression of p53, cleaved PARP and Bax/Bcl2 ratio normalized expression. β-Actin was used as loading control. b) Quantitative analysis of mRNA expression levels of Bax and Bcl-2 in mesothelioma cell lines after 24, 48 and 72 h of CBP treatment. The bars represent ± the average ± SD of independent experiments (n = 3). Statistically significant difference compared to untreated cells: **p ≤ 0.01, ***p ≤ 0.005. CTRL: untreated cells after 72 h culture