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. 2019 Aug 16;38:360. doi: 10.1186/s13046-019-1368-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — In vivo anticancer properties of CBP. a) Antitumor effect of CBP in a xenograft model of MM. The tumor growth curves show that CBP was able to significantly delay the growth of the ectopic tumors as compared to the controls (p-value = 0.0013), but with lower efficacy, compared to cisplatin (p-value = 0.0011). b) Effects of CBP on cell proliferation apoptosis and angiogenesis as compared to the control, as determined by Ki67, TUNEL (asterisks identify apoptotic cells) and CD34 staining (original magnification × 10). CBP treatment significantly decreased cell proliferation (25% vs 10%; p-value = 0.008), increased apoptosis (8% vs 2%; p-value = 0.0005) and decreased angiogenesis (5 ± 2 vs 10 ± 4; p-value = 0.0006)