Table 4.

Multiple linear regression analysis of the associations between change in fat depots and HOMA-IR and Matsuda Index at 10- to 11-year follow-up, adjusted for covariates including BMI

Independent variables from baseline in the model	Dependent Variable
	10-year HOMA-IR		10-year Matsuda Index
	β	p-value	β	p-value
Model 1
Age	−0.002667	0.247	0.000808	0.684
Female	0.017029	0.762	0.002308	0.962
Positive family history of diabetes	−0.018039	0.704	−0.011035	0.803
IAFA, baseline	0.003423	<0.001	−0.006612	<0.001
10-year Change in IAFA	0.003175	<0.001	−0.003534	<0.001
BMI, baseline	0.013890	0.183	−0.007395	0.399
HOMA-IR, baseline	0.118381	<0.001
Matsuda Index, baseline			0.115637	<0.001
IAFA2			0.000018	0.007
R-squared	0.375900		0.433600
Model 2
Age	−0.001997	0.409	−0.000109	0.956
Female	0.026140	0.723	0.014707	0.821
Positive family history of diabetes	−0.008498	0.857	−0.027883	0.515
IAFA, baseline	0.003574	<0.001	−0.008288	<0.001
10-year Change in IAFA	0.002648	0.002	−0.002272	0.003
Abdominal SCFA, baseline	−0.000261	0.647	0.000145	0.766
10-year Change in Abdominal SCFA	0.000848	0.180	−0.001962	0.001
BMI, baseline	0.016761	0.233	−0.006690	0.587
HOMA-IR, baseline	0.122345	<0.001
Matsuda Index, baseline			0.120003	<0.001
IAFA2			0.000025	0.001
R-squared	0.381000		0.458600
Model 3
Age	−0.003093	0.202	0.000411	0.396
Female	0.095811	0.342	−0.088020	0.141
Positive family history of diabetes	−0.013076	0.786	−0.017572	0.816
IAFA, baseline	0.003296	<0.001	−0.002844	<0.001
10-year Change in IAFA	0.003160	<0.001	−0.003531	<0.001
Thigh SCFA, baseline	−0.001468	0.287	0.001949	0.072
10-year Change in thigh SCFA	−0.000047	0.970	−0.000423	0.534
BMI, baseline	0.023770	0.073	−0.020959	0.055
HOMA-IR, baseline	0.116287	<0.001
Matsuda Index, baseline			0.115350	<0.001
IAFA2			0.000021	0.003
R-squared	0.37740		0.44410

^*IAFA, intra-abdominal fat area, SCFA, subcutaneous fat area; HOMA-IR, HOMA for insulin resistance;