Fig. 1.

Overview of the MSC secretome. The secretome comprises of soluble proteins and secreted extracellular vesicles. The proteins include biologically active factors such as cytokines (e.g., interleukin 10, and tumor necrosis factor-α), chemokines (e.g., eotaxin-3), and growth factors (e.g., hepatocyte growth factor and transforming growth factor-β isoform 3). The vesicular factors include exosomes and microvesicles