Figure 3.

(a–h) Posttransplant biopsy characteristics (results from all indications and protocol [1-, 3-, and 12-month] biopsies up to July 2018). Case 1 is represented on the left-hand column and case 2 is represented on the right-hand column. Graphs (a) and (b) show the serum creatinine at time of biopsy for case 1 and 2, respectively. Graphs (c) and (d) are the estimated portion of the biopsy section that is affected by crystals and show initial decline, followed by stable levels after allopurinol and/or feboxustat therapy in both patients. Graphs (e) and (f) show the estimated distribution of crystals seen on the renal biopsy: luminal, epithelial, and interstitial compartments. Graphs (g) and (h) demonstrate the tubular atrophy and interstitial fibrosis associated with crystal nephropathy, with severe chronic scores (Banff criteria) seen within the first 12 months posttransplantation.