Table 4.

Risk factors associated with death-censored graft failure

Variables	Univariate analyses			Multivariable analyses
	HR	P	95% CI	HR	P	95% CI
Female	0.96	0.87	0.61–1.50
Age/yr	0.98	0.04	0.97–0.99	0.98	0.21	0.97–1.0
White	1.65	0.10	0.89–3.05
Diabetes as a cause of ESRD	1.31	0.27	0.80–2.11
Repeat transplant	1.07	0.80	0.63–1.80
Living donor	0.84	0.44	0.54–1.31
Depleting induction	0.71	0.16	0.44–1.14
Clinically indicated biopsy	4.61	0.009	1.46–14.64	1.99	0.27	0.57–6.89
Any DSA (yes/no)	0.62	0.06	0.38–1.01
Interval from transplant to the index biopsy (per month)	1.01	<0.001	1.0–1.01	1.004	0.003	1.0–1.01
dnDSA	0.93	0.86	0.40–2.13
Pretransplant DSA	1.0	0.95	1.9–8.67
Persistent DSA	1.30	0.33	0.76–2.23
Class II DSA	0.78	0.56	0.34–1.77
DSA MFIsum > 1000	0.84	0.55	0.48–1.47
Immunodominant DSA >1000	0.89	0.69	0.51–1.56
DP DSA	0.51	0.50	0.07–3.7
DQ DSA	0.68	0.32	0.33–1.43
DR DSA	0.50	0.24	0.15–1.59
eGFR at time of biopsy	0.96	<0.001	0.95–0.97	0.96	<0.001	0.95–0.98
UPC at time of biopsy	3.44	<0.001	2.23–5.30	2.01	0.002	1.32–3.29
cg score > 0	4.02	<0.001	2.28–7.07	1.39	0.34	0.71–2.73
Sum chronicity score	1.40	<0.001	1.29–1.52	1.21	<0.001	1.09–1.34
Subsequent acute rejection	1.55	0.10	0.91–2.65

CI, confidence interval; dnDSA, de novo donor-specific antibodies; DSA, donor-specific antibodies; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; MFI, mean fluorescent intensity; UPC, urine protein-to-creatinine ratio.

P values that are statistically significant (P < 0.05) are in bold.