Table 1.
Clinicopathologic Features and Genotyping Data in 15 choriocarcinomas
| Case N | Age (y) | Clinical Presentation | β-hCG at Presentation (mIU/mL) | gestation history | antecedent gestation | Specimen | Diagnosis | Genotyping | causative pregnancy | Therapy, Disease Status, Follow-up (mo) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 28 | Vaginal bleeding, | 2770 |
G4P1 Term(2 y ago) IA(3y,1y ago) |
Missed abortion (2 monthes ago) |
Hysterectomy tumor |
CC |
Gestational Biparental,XX |
abortion/ term |
TP (4 cycles); +EME-CO (4 cycles);+EP-EMA(3 cycles)+ Hysterectomy; NED (33) |
| 2 | 32 | Vaginal bleeding, | 37,382 |
G3P1 Term(10 y ago) MA(8 y ago) |
Missed abortion (4 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Occult Homozygous CHM |
TP (2 cycles) NED (25) |
| 3 | 32 | Vaginal bleeding, | 6067 |
G4P2 Pre tern(13 y ago) Term(12,2y ago) |
Missed abortion (14 monthes ago) | Uterine curetting | CC |
Gestational Biparental,XY |
missed abortion / term |
TP (4 cycles); +EME-CO (6 cycles);+ Hysterectomy NED (44) |
| 4 | 10 |
lower abdominal, pain; Vaginal bleeding, |
297,475 | G0P0 | no | Ovary, pelvic tumor | CC | Nongestational (tumor matches maternal tissue) | no |
BEP(6 cycles) Lost to follow-up(6) |
| 5 | 55 | Vaginal bleeding, | 531 | G3P1 | CHM,(7 y ago) |
Uterine curetting + mole |
CC | Gestational, androgenetic, XX |
antecedent Homozygous CHM |
MTX(3 cycles), Hysterectomy, NED(23) |
| 6 | 34 | Vaginal bleeding, | 22,586 |
G2P2 Term(12 y ago) |
Term(4 weeks ago) |
Uterine curetting + placenta |
CC | Gestational Biparental,XY |
Term pregnancy |
EME-CO (7 cycles) NED (23) |
| 7 | 37 | rising β-HCG | 98 |
G3P2, CHM(7 y ago) |
Term(5 y ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Heterzygous CHM |
EME-CO (7 cycles) NED (23) |
| 8 | 37 | lower abdominal pain | 118 |
G5P1 Term(10 y ago) SA(12y、5 y ago) IA(13y、2 y ago) |
IA(2 y ago) | Right ovary | CC | Gestational, androgenetic XX |
Occult Homozygous CHM |
EME-CO (7 cycles) NED (29) |
| 9 | 23 | rising β-HCG | 160 | G2P1 | CHM,(9 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Homozygous CHM |
MTX(4 cycles), 5-FU* (4 cycles), EMA-CO (4 cycles) NED (45) |
| 10 | 21 | lower abdominal pain | > 800,000 | G0P0 | no |
Pelvic tumor +Concurrent placenta |
CC |
Gestational, (biparental XY+ Androgenetic XX) |
Occult Homozygous CHM/ twim one CHM |
EMA-CO (3 cycles) Termination chemothrapy, NED (51) |
| 11 | 20 | Vaginal bleeding, | 18,973 | G0P0 | no | Right ovary | CC |
Gestational, Biparental,XY |
Occult SP |
EMA-CO (7 cycles) NED (60) |
| 12 | 35 | Vaginal bleeding, + rising β-HCG | 14,774 |
G6P2 DA(10y,10y,12y, 12y ago) Term(5y ago) |
Term(8 weeks ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Occult Heterzygous CHM |
MTX(3 cycles) + ACTD(5 cycles) NED (10) |
| 13 | 31 | Vaginal bleeding, | > 1000 | G1P1 | Term(12 weeks ago) | Uterine curetting | CC |
Gestational, Biparental,XX |
Term pregnancy |
EMA (6ycles) + TP (4ycles) NED (8) |
| 14 | 54 | lower abdominal pain | 9135 |
G4P1 IA(32y, 31y,28y,ago) Term(29y ago) |
CHM,(2 monthes ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Homozygous CHM |
EMA-CO(2 cycles) + TP(2 cycles) + Hysterectomy NED (5) |
| 15 | 28 | Vaginal bleeding | 21,154 |
G6P1 IA(5y, 4y,3y,2y,2y ago) |
Term(8 weeks ago) | Uterine curetting | CC | Gestational, androgenetic, XX |
Occult Homozygous CHM |
MTX (4 cycles) NED (7) |
BEP bleomycin, etoposide, cisplatin, CC Choriocarcinoma, DA drug abortion, EMA etoposide, methotrexate, actinomycin D, EMA-CO etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine, IA induced abortion, MA missed abortion, NED no evidence of disease, SA spontaneous abortion, TP, paclitaxel-cisplatin