Table 1:

miRNA and lncRNA regulating SIRT1 levels

Name	Effect on SIRT1 Levels	Functions	References
miR-199a-5p	Decrease	Regulates the pathogenesis of intrauterine growth restriction	[27]
miR-361–5p	Decrease	Promotes hepatic triglyceride accumulation and insulin sensitivity during hepatosteatosis	[28]
miR-34a	Decrease	1) Suppresses proliferation and apoptosis of gastric cancer 2) Regulates pro-apoptotic caspase-3/7 activity and p53 levels in cardiac progenitor cells 3) Regulates plasma and hepatic Fgf21 during obesity and insulin resistance	[29], [32], [35]
miR-29b	Decrease	Reverses oxaliplatin-resistance in colorectal cancer by enhancing ROS and JNK phosphorylation to induce apoptosis	[30]
miR-30a	Decrease	Suppresses lung cancer progression	[31]
miR-221	Decrease	Promotes white adipose tissue inflammation and insulin-resistance	[33]
miR-204	Decrease	In prostate cancer indices mitochondrial apoptosis through upregulation of Noxa and Puma via acetylated p53	[34]
miR-181a	Decrease	Induces gastric cancer apoptosis by increasing FoxO1 acetylation during oxidative stress	[36]
IncRNA NEAT1	Increase	Promotes cell proliferation and metastasis in colorectal cancer by competing with miR-34a leading to upregulation of Wnt/βcatenin signaling	[37]
IncRNA MALAT1	Increase	In high glucose represses SIRT1 transcription by interacting with FoxO1 to induce HK-2 cell injury	[38]
IncRNA-PRLB	Increase	Promotes breast cancer by targeting miR-4766–5p to increase SIRT1 levels	[39]
LncRNA HNF1A-AS1	Increase	Promotes colon cancer metastasis by increasing SIRT1 levels through targeting miR-34a to induce noncanonical Wnt signaling	[40]
LncRNA HULC	Increase	Inhibits SIRT1 degradation to promote protective autophagy in hepatocellular carcinoma	[41]