. Author manuscript; available in PMC: 2020 Sep 1.

Published in final edited form as: Curr Environ Health Rep. 2019 Sep;6(3):80–94. doi: 10.1007/s40572-019-00232-w

Table 1.

Selected examples of chemicals associated with fatty liver disease.

Category	Chemical / Chemical Group	Laboratory animals	Epidemiology/Clinical Evidence
POPs	Dioxins	Adult Exposure [92–95, 62, 96, 63]	[97–99]
	Polychlorinated biphenyls	Adult Exposure [12, 23, 56, 65, 92, 59, 58, 67].	[66, 97, 98,100–104]
	Perfluorooctanoic acid	Adult Exposure [80, 105, 74, 106]	[83–85, 107–109].
	Perfluorooctanesulfonic acid	Adult Exposure [110–112, 78]	[108, 109, 84, 107]
	Perfluorooctanesulfonic acid	Developmental Exposure [113]
	Polybrominated diphenyl ethers	Adult Exposure [114]
	Diethylhexyl phthalate	Adult Exposure [115, 116]
	Diethylhexyl phthalate	Developmental Exposure [117]
	Organochlorine Insecticides	[118–120]	[101, 97, 99]
	Atrazine	Adult Exposure [121–123]
VOCs	Vinyl Chloride/Metabolites	Adult Exposure [27, 28, 14]	[4, 29].
	Smoking/nicotine	Adult Exposure [124, 125]	[126, 127]
	Tributyltin	Adult Exposure [128]
	Tributyltin	Developmental Exposure [129–131]
	Air Pollution / Particulate Matter	Adult Exposure [132–135]	[136]
	Benzo[a]pyrene	Adult Exposure [137]
	Benzo[a]pyrene	Developmental Exposure [138]
Metals	Arsenic	Adult Exposure [139–143]	[145]
	Arsenic	Developmental Exposure [144]
	Lead		[100, 146]
	Mercury	Adult Exposure [147, 148]	[100]
	Cadmium	Adult Exposure [149–151]	[152, 153]
Others	Bisphenol A	Developmental Exposure [154–157]
	Fungicides	Adult Exposure [92, 158]
	Fungicides	Developmental Exposure [92]
	Glyphosate-based herbicides	Adult Exposure [159]	[160]
	Dinoseb	Adult Exposure [161]