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. Author manuscript; available in PMC: 2019 Aug 18.
Published in final edited form as: Mol Psychiatry. 2019 Feb 18;25(11):2932–2941. doi: 10.1038/s41380-019-0375-7

Figure 3. Association of iron burden and other neuropathological features with antecedent cognitive decline.

Figure 3.

Associations between plaque, NFT and iron (inferior temporal cortex) and change in the global cognition score in the years prior to death in post mortem cases stratified by NIA Reagan criteria into high AD pathology (moderate and high pathology; n=126; A-E) and low AD pathology (no or low pathology; n= 83; F-J). Data are from mixed effects linear models with covariates: age, sex, APOE ε4, plaque burden, NFT, Lewy bodies, gross vascular infarcts, years of education, and inferior temporal iron. Inferior temporal iron, NFT and plaque were included as continuous variables in modeling, but stratified in tertiles for visual display. Lewy bodies and gross infarcts were dichotomous variables (presence/absence). Data are means +/− standard error.