Table 1. Subject characteristics.

High AD pathology indicates classification of moderate or high pathology on NIA/Reagan criteria, Low AD pathology indicates classification of no or low pathology using NIA/Reagan criteria. Low AD pathology post mortem in subjects with a diagnosis of AD in life indicates clinical misdiagnosis.

AD Pathology (NIA/Reagan)	Low	Low	High	High
Clinical diagnosis	Cognitively Normal	Alzheimer’s	Cognitively Normal	Alzheimer’s
N	69	14	71	55
Age at death: mean (S.D.)	87∙8 (6∙0)	92∙9 (4∙5)	89∙9 (6∙5)	90∙7 (5∙1)
Female sex: n (%)	23 (33%)	7 (50%)	20 (28%)	19 (35%)
APOE ε4: n (%)	5 (7%)	2 (14%)	23 (32%)	15 (27%)
Education years: mean (S.D.)	14∙5 (2∙6)	14∙6 (2∙4)	14∙5 (2∙4)	15∙1 (2∙8)
Presence of Lewy bodies: n (%)	9 (13%)	6 (43%)	9 (13%)	15 (27%)
Presence of gross infarcts: n (%)	19 (28%)	8 (57%)	30 (42%)	25 (45%)
Presence of microinfarcts: n (%)	15 (22%)	4 (29%)	23 (32%)	20 (36%)