| Methods |
Adequate allocation generation, double‐blind, no ITT |
| Participants |
Volunteers |
| Interventions |
Ciprofloxacin: 10 x 500 mg versus placebo |
| Outcomes |
Eradication, resistance developed, failure serogroup adverse effects
Follow‐up: 2 weeks |
| Notes |
Main serogroup: B |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Adequate allocation generation |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
No ITT |
| Selective reporting (reporting bias) |
Low risk |
No evidence |
| Other bias |
Low risk |
No evidence |
