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. 2019 Aug 13;12:6461–6470. doi: 10.2147/OTT.S203724

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© 2019 Zhou et al.

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HIF1α induces PD-L1 expression in FTC cells under hypoxia condition. FTC cells were transfected with siHIF1α or siPD-L1 or the negative control (siControl). The expressions of HIF1α (A) and PD-L1 (B) in TT cells were determined by immunofluorescence staining. (C) The mRNA and protein expressions of HIF1α and PD-L1 in TT cells were determined by qRT-PCR and Western blot. (D) The mRNA and protein expressions of HIF1α and PD-L1 in FTC-133 cells were determined by qRT-PCR and Western blot. Data presented as mean ± SD, ***p<0.001. Scale bar=20 μm.

Abbreviations: HIF-1α, hypoxia-inducible factor 1α; PD-L1, programmed cell death-1 protein ligand 1.