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HIF1α/PD-L1 signaling mediates FTC cell apoptosis. TT and FTC-133 cells were transfected with siHIF1α or siPD-L1 or the negative control (siControl). Cell apoptosis was determined by TUNEL staining in TT (A) and FTC-133 (B) or by Annexin V staining in TT (C, D) and FTC-133 (E, F). Data presented as mean ± SD, *p<0.05, **p<0.01, ***p<0.001. Scale bar=20 μm.
Abbreviations: HIF-1α, hypoxia-inducible factor 1α; PD-L1, programmed cell death-1 protein ligand 1.
