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. 2019 Aug 13;12:6461–6470. doi: 10.2147/OTT.S203724

Table 1.

The relationships between PD-L1 and HIF1α expression and clinicopathologic characteristics of 85 thyroid carcinoma patients

Variables No. PD-L1 p HIF1α p
Positive Negative Positive Negative
Total 85 57 28 64 21
Age (years) 0.885 0.856
 <45 48 32 16 37 11
 ≥45 37 25 12 27 10
Sex 0.159 0.880
 Male 32 18 14 26 6
 Female 53 39 14 41 12
Tumor size (mm3) 0.010* 0.055
 ≥40 57 44 13 47 10
 <40 28 13 15 17 11
T Stage 0.030* 0.084
 T1 and T2 49 38 11 33 16
 T3 36 19 17 31 5
Lymphocytic thyroiditis 0.219 0.051
 Yes 39 23 16 25 14
 No 46 34 12 39 7
TNM 0.005** 0.002**
 Ⅰ+Ⅱ 47 38 9 42 5
 Ⅲ+Ⅳ 38 19 19 22 16
Metastasis 0.000*** 0.000***
 Yes 35 15 20 18 17
 No 50 42 8 46 4
Psammoma body 0.914 0.268
 Yes 12 5 7 7 5
 No 73 52 21 57 16
Calcification in stoma 0.442 0.116
 Yes 43 31 12 36 7
 No 42 26 16 28 14
PD-L1 0.000***
 Positive 67 59 8
 Negative 18 5 13

Note: *p<0.05, **p<0.01, ***p<0.001.

Abbreviations: HIF-1α, hypoxia-inducible factor 1α; PD-L1, programmed cell death-1 protein ligand 1.