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. 2019 May 2;47(14):e79. doi: 10.1093/nar/gkz320

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Analysis of the rs227727 linkage disequilibrium (LD) block (hg19, chr17:54,752,926-54,778,620). (A, B) Negative decimal logarithm of the TAGOOS P-value for the +87 kb NOGGIN (chr17:54,754,994-54,757,864) and +105 kb NOGGIN regions (hg19,chr17:54,776,180-54,777,328) with common SNPs (Red points) and the previously validated SNP rs227727 (Blue triangle). The horizontal dashed line stands for the significance threshold. (C) Percentage of SNPs in the rs227727 LD block with significant and non-significant TAGOOS scores annotated with each transcriptional regulator from the ReMap database ordered by the decreasing difference between the blue (TAGOOS Signif) and red (TAGOOS Non-signif) lines (P_Wilcoxpaired = 2.2 × 10⁻¹⁶). (D) Zoom into the first ten transcription factors of subfigure (C). (E) Mouse craniofacial phenotype annotation enrichment of TFs with highest (Signif TAGOOS) or lowest (Non-signif TAGOOS) binding difference between TAGOOS-significant and non-significant SNPs.