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. 2019 May 25;47(14):7418–7429. doi: 10.1093/nar/gkz466

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — PARP-1 restricts somatic hypermutation in vivo. (A) Experimental setup to analyze somatic hypermutation in germinal center (GC) B cells of mice. (B) Sequence analysis of SHM in the JH₄ intron in three pairs of WT and PARP-1^−/− mice. Numbers in the pie charts indicate numbers of analyzed sequences; relative amounts of sequences with the indicated number of mutations are given. Mutation frequencies are compared by a two-sided Fisher's exact test. (C) Mutation pattern (top: absolute, bottom: relative) of unique mutations in WT and PARP-1^−/− mice for the analysis shown in (B). Significance analysis: two-sided Fisher's exact test.