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. 2019 Jul 19;4(3):431–442. doi: 10.1002/epi4.12351

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© 2019 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cannabidiol (CBD) (150 mg/kg) administration decreases TMEV‐induced seizures observed at 4 h post‐CBD treatment but not at 9 h post‐CBD treatment. A, CBD (150 mg/kg) treatment (i.p. every 12 h for 5 d starting at 3 dpi) does not affect frequency (upper panel) and severity (lower panel) of all the behavioral seizures observed during 3‐7 dpi. B, Analysis of seizures observed at 4 h post‐CBD treatment shows a significant reduction in the average number of seizures (upper panel) and the average cumulative seizure burden at 6 and 7 dpi (lower panel) compared to the vehicle group. C, CBD (150 mg/kg) treatment does not affect seizure endpoints observed at 9 h posttreatment. Statistics: unpaired t test (upper panels in (A) and (C)), Welch's t test (upper panel in (B)), Scheirer‐Ray‐Hare test and Sidak’s multiple comparison test (all lower panels), ^* P < 0.05, ^*** P < 0.001, n = 20 mice per group.