Figure 4.

Rats exposed to GB and treated with atropine sulfate and HI‐6 at onset of toxic signs and with diazepam monotherapy (GB/DZP; n = 7) 30 min after seizure onset lost significant weight by 24 h after exposure. Shown are body weight changes in rats that were evaluated daily (M‐F) over a 90‐d period after GB exposure. Body weight remained less than baseline and less than air control (Air control/No GB; n = 6) on post‐exposure days (PED) 1 and 2 (**P < 0.01). In contrast, rats exposed to GB that received pregnanolone and diazepam dual therapy (GB/DZP/PREG; n = 8) were not different from Air control/No GB initially after exposure, had significant gain above their baseline by PED 5 and by 2 mo after exposure weighed more than air control rats (P < 0.05). GB‐exposed rats tended to gain more weight than air control by 3 mo after exposure but this did not reach significance. B, Rats that received diazepam and pregnanolone dual therapy (n = 16) 30 min after GB‐induced seizure onset had greater reduction in body temperature between 1 and 6 h after exposure compared to air control rats treated with diazepam (n = 15; *P < 0.05). All groups had reduced body temperature compared with their baseline, with air control having reduced temperature 1‐4 h after air exposure, GB/DZP rats having reduced body temperature 2‐7 h after exposure and GB/DZP/PREG reducing temperature 1‐8 h after exposure