Table 3.
Bivariate regressions of independent variables with dependent plasma TFV concentrations, HPTN 067 daily dosing arm participants (All Sites; Weeks 18/30 Data Combined; 161 participants, n=302 records), July 2012-May, 2014.
| Variable | exp(β) (95% Confidence Interval) | p-value |
|---|---|---|
| Age | 1.04 (0.99- 1.08) | 0.10 |
| Less Than Secondary Education | 0.29 (0.14- 0.60) | <0.01 |
| Perceived Problematic Drug Use, Past 3 Months | 0.17 (0.05- 0.64) | <0.01 |
| Perceived Problematic Drinking, Past 6 Months | 1.36 (−0.64- 3.37) | 0.18 |
| Perceived Low Control Over HIV Infection | 0.55 (0.28- 1.07) | 0.08 |
|
Low Perceived External Support for PrEP
Scale (Range: 0-2) |
0.57 (0.38- 0.85) | <0.01 |
|
Participant-Staff Disclosure Challenges
Scale (Range 0-4) |
0.58 (0.42- 0.78) | <0.01 |
| Staff Judge Patient | 2.15 (1.01- 4.40) | 0.04 |
| Staff Have Negative Reactions to PrEP Pill Taking | 0.34 (0.10- 1.22) | 0.10 |
| Low Staff Support for PrEP Pill Taking | 1.46 (0.54- 3.99) | 0.46 |
| Study-Related Side Effects | 2.41 (1.05- 5.53) | 0.04 |
| Weight (At weeks 18 and 30; Kg) | 0.98 (0.96- 0.99) | 0.04 |
| Creatinine Clearance (mL/min) | 0.99 (0.97- 1.00) | 0.15 |
| Self-report Days Since Last Dose | 0.70 (0.62- 0.79) | <0.01 |
| Study Site (ref. Cape Town) | ||
| Bangkok | 5.12 (2.22- 11.8) | <0.01 |
| Harlem | 0.53 (0.23- 1.26) | 0.15 |