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. 2019 Jun 28;47(14):7163–7181. doi: 10.1093/nar/gkz531

Figure 2.

Figure 2.

Translesion synthesis. TLS pathways are regulated by PCNA K164 ubiquitination or REV1. PCNA Ub can also interact with REV1 directly, as with other TLS polymerases. PAF15 is degraded upon fork stalling, which allows PCNA to interact with TLS polymerases. RPA recruits RAD6/RAD18 ligase that can ubiquitinate PCNA to recruit TLS polymerases. SPRTN binds PCNA Ub preventing PCNA deubiquitylation. After TLS is completed, the TLS polymerase replaced again by the replicative polymerase. In the REV1-dependent pathway, REV1 can recruit other TLS polymerases. Figure adapted from (23).